AZD4144
AZD4144 is a potent, selective NLRP3 inflammasome inhibitor (IC50 = 54 nM) that competitively displaces MCC950. It effectively reduces IL-1β and IL-18 release in cellular assays and is a valuable research tool for studying NLRP3-driven pathologies like inflammatory and autoimmune diseases in both in vitro and in vivo models.
Product Specifications
CAS Number
2890191-41-8
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
99.02% (May vary between batches)
Solubility
DMSO:100 mg/mL (263.62 mM)
Smiles
OC1=C (C=2C3=C (C (NC[C@@H] (CO) O) =NN2) C=CC=C3) C=CC (C (F) (F) F) =C1
Molecular Formula
C18H16F3N3O3
Molecular Weight
379.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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