(1S,2S) -ML-SI3
(1S,2S) -ML-SI3 is the (-) -trans-isomer and a potent TRPML1/2 inhibitor, with weaker activity against TRPML3. Its (+) -enantiomer conversely inhibits TRPML1 but activates TRPML2/3. This stereospecific modulation makes it a valuable chemical tool for studying lysosomal ion channel function in cellular and biochemical assays.
Product Specifications
CAS Number
2563870-87-9
Field of Research
Pharmacology & Drug Discovery
Smiles
N (S (=O) (=O) C1=CC=CC=C1) [C@@H]2[C@H] (CCCC2) N3CCN (CC3) C4=C (OC) C=CC=C4
Molecular Formula
C23H31N3O3S
Molecular Weight
429.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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