5-HT7R antagonist 2
Compound 4h is a selective 5-HT7 receptor antagonist with a K_i of 67 nM, disrupting both G protein and β-arrestin signaling. It shows potential for autism-related research by mitigating repetitive behaviors and restoring impaired neurogenesis, supported by pharmacokinetic data from mouse studies.
Product Specifications
CAS Number
1448808-50-1
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
N1=C (NCC1) C2=CC=CC (=C2) C3=CC=CC=C3OC
Molecular Formula
C16H16N2O
Molecular Weight
252.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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