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5-HT7R antagonist 2

Compound 4h is a selective 5-HT7 receptor antagonist with a K_i of 67 nM, disrupting both G protein and β-arrestin signaling. It shows potential for autism-related research by mitigating repetitive behaviors and restoring impaired neurogenesis, supported by pharmacokinetic data from mouse studies.

Product Specifications

CAS Number

1448808-50-1

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Smiles

N1=C (NCC1) C2=CC=CC (=C2) C3=CC=CC=C3OC

Molecular Formula

C16H16N2O

Molecular Weight

252.31

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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