Malotilate
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM) . Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes[1][2].
Product Specifications
CAS Number
59937-28-9
Product Name Alternative
NKK 105
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/malotilate.html
Purity
99.47
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS\1
Molecular Formula
C12H16O4S2
Molecular Weight
288.38
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-LOX
Available Sizes
Frequently Asked Questions
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