Rel-VU6021625

Rel-VU6021625 is the relative configuration of VU6021625 (HY-160440A) . VU6021625 is a potent and selective mAChR M4 antagonist with IC50 values of 0.44 nM and 57 nM for human M4, rat M4, respectively[1].

Product Specifications

CAS Number

[2307718-96-1]

UNSPSC

12352005

Target

Drug Isomer; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/rel-vu6021625.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H][C@@](C1)(CN(C2)CC3CCOCC3)[C@@]2([H])C[C@H]1NC4=CC=C(C5=CC6=CN(C)N=C6C=C5)N=N4

Molecular Formula

C25H32N6O

Molecular Weight

432.56

References & Citations

[1]Moehle MS, et al. Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy. ACS Pharmacol Transl Sci. 2021 Aug 2;4 (4) :1306-1321.