Rel-VU6021625
Rel-VU6021625 is the relative configuration of VU6021625 (HY-160440A) . VU6021625 is a potent and selective mAChR M4 antagonist with IC50 values of 0.44 nM and 57 nM for human M4, rat M4, respectively[1].
Product Specifications
CAS Number
[2307718-96-1]
UNSPSC
12352005
Target
Drug Isomer; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rel-vu6021625.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@@](C1)(CN(C2)CC3CCOCC3)[C@@]2([H])C[C@H]1NC4=CC=C(C5=CC6=CN(C)N=C6C=C5)N=N4
Molecular Formula
C25H32N6O
Molecular Weight
432.56
References & Citations
[1]Moehle MS, et al. Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy. ACS Pharmacol Transl Sci. 2021 Aug 2;4 (4) :1306-1321.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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