Antifungal agent 92

Compound 21 (Antifungal agent 92) is a small molecule fungicide effective against Sclerotinia sclerotiorum (EC50 = 4.4 μM) . Its primary mode of action involves mitochondrial disruption, evidenced by impaired membrane potential, elevated ROS, and morphological changes, alongside inhibition of complexes II and III. This profile supports its use in studying fungal pathogenesis and mitochondrial function in vitro.