BBO-8520
BBO-8520 is a first-in-class dual-state KRASG12C inhibitor that covalently binds to the Switch-II pocket, blocking signaling in both ON and OFF conformations. It demonstrates potent activity in growth factor-stimulated in vitro assays and induces durable tumor regression in vivo, including in models resistant to OFF-state-only inhibitors. This makes it a valuable tool for oncology research targeting KRAS-driven cancers.
Product Specifications
CAS Number
2893809-51-1
Product Name Alternative
BBO8520
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
97.87% (May vary between batches)
Solubility
DMSO:≥ 40 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.74 mM)
Smiles
N#CC1=C (SC2=C (F) C=CC (=C12) C=3C (F) =C4N=C (N=C (C4=CC3C (F) (F) F) N5CC (N (C (=O) C=C) CC5C) C) OCC67N (CCC6) CC (F) C7) N
Molecular Formula
C35H33F6N7O2S
Molecular Weight
729.74
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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