BBO-8520
BBO-8520 is a first-in-class dual-state KRASG12C inhibitor that covalently binds to the Switch-II pocket, blocking signaling in both ON and OFF conformations. It demonstrates potent activity in growth factor-stimulated in vitro assays and induces durable tumor regression in vivo, including in models resistant to OFF-state-only inhibitors. This makes it a valuable tool for oncology research targeting KRAS-driven cancers.
Product Specifications
CAS Number
2893809-51-1
Product Name Alternative
BBO8520
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
97.87% (May vary between batches)
Solubility
DMSO:≥ 40 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.74 mM)
Smiles
N#CC1=C (SC2=C (F) C=CC (=C12) C=3C (F) =C4N=C (N=C (C4=CC3C (F) (F) F) N5CC (N (C (=O) C=C) CC5C) C) OCC67N (CCC6) CC (F) C7) N
Molecular Formula
C35H33F6N7O2S
Molecular Weight
729.74
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Porcine Apoptosis Associated Tyrosine Kinase ELISA kit
Recombinant Prochlorococcus marinus Divinyl chlorophyll a/b light-harvesting protein pcbC (pcbC)