DCLK1-IN-5
DCLK1-IN-5 (Compound a24) is a potent DCLK1 inhibitor (IC50 = 179.7 nM) that suppresses inflammation by blocking DCLK1-dependent IKKβ phosphorylation. It has demonstrated protective effects in murine models of LPS-induced lung injury and sepsis, making it a valuable research tool for studying inflammatory pathways in vitro and in vivo.
Product Specifications
CAS Number
3028774-14-0
Field of Research
Protein Biochemistry, Signal Transduction
Smiles
S (C (C) C) (=O) (=O) C1=C (NC2=NC (NC3=C (OC) C=C (NC (=S) N4CCN (C) CC4) C=C3) =NC=C2Cl) C=CC=C1
Molecular Formula
C26H32ClN7O3S2
Molecular Weight
590.16
Storage Conditions
-20°C
Notes
For research use only.
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