Divarasib adipate
Divarasib (GDC-6036) adipate is an orally bioavailable, covalent KRAS G12C inhibitor with sub-nanomolar potency (IC50 <0.01 μM) . It irreversibly binds the switch-II pocket, locking KRAS in its inactive GDP-bound conformation, and is used in both in vitro biochemical assays and in vivo cancer research models.
Product Specifications
CAS Number
2762240-36-6
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (CCC (O) =O) CC (O) =O.FC=1C2=C (C (=NC (OCC3N (C) CCC3) =N2) N4C (C) CN (C (C=C) =O) CC4) C=C (Cl) C1C5=C (C (F) (F) F) C (C) =CC (N) =N5
Molecular Formula
C35H42ClF4N7O6
Molecular Weight
768.2
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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