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E3 ligase Ligand 22

E3 Ligase Ligand 22 (compound 139) is a cereblon-binding molecule that induces the ubiquitin-proteasomal degradation of transcription factors Ikaros and Aiolos. This mechanism of action makes it a valuable chemical probe for targeted protein degradation research in both cellular and in vivo models of hematological cancers.

Product Specifications

CAS Number

2377849-57-3

Field of Research

Molecular Biology, Pharmacology & Drug Discovery

Smiles

N (CC1=CN (N=C1) C2CCN (CC3 (C) CCC3) CC2) C4=C5C (C (=O) N (C5=O) C6C (=O) NC (=O) CC6) =CC=C4

Molecular Formula

C28H34N6O4

Molecular Weight

518.61

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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