E3 ligase Ligand 22
E3 Ligase Ligand 22 (compound 139) is a cereblon-binding molecule that induces the ubiquitin-proteasomal degradation of transcription factors Ikaros and Aiolos. This mechanism of action makes it a valuable chemical probe for targeted protein degradation research in both cellular and in vivo models of hematological cancers.
Product Specifications
CAS Number
2377849-57-3
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Smiles
N (CC1=CN (N=C1) C2CCN (CC3 (C) CCC3) CC2) C4=C5C (C (=O) N (C5=O) C6C (=O) NC (=O) CC6) =CC=C4
Molecular Formula
C28H34N6O4
Molecular Weight
518.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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