EGFR kinase inhibitor 4
EGFR Kinase Inhibitor 4 is a potent bivalent ATP-allosteric inhibitor of mutant EGFR (L858R/T790M/C797S), exhibiting an IC50 of 1.8 nM. It is a key research tool for investigating resistance mechanisms and therapeutic strategies in non-small cell lung cancer (NSCLC) models, both in vitro and in vivo.
Product Specifications
CAS Number
2922402-05-7
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction
Smiles
C (C) C=1NC (=C (N1) C2=CC (NC (=O) C3=C4C (NC=5C (C (=O) N4) =CC=CC5) =CC=C3) =CC=C2) C=6C=C (NC7=C (OC) C=CC (NC (C=C) =O) =C7) N=CC6
Molecular Formula
C40H34N8O4
Molecular Weight
690.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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