EGFR T790M/L858R-IN-7
EGFR T790M/L858R-IN-7 (Compound 72) is a potent and selective pyrimidine-based inhibitor of EGFR T790M/L858R mutants, achieving 93% inhibition at 0.05 μM through direct kinase domain binding. This compound is a valuable chemical probe for in vitro biochemical assays and cellular studies investigating resistance mechanisms in non-small cell lung cancer research.
Product Specifications
CAS Number
3032760-90-7
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C=1N=C (N2C=3C (C=C2) =CC=CN3) C=CN1) C4=C (OC) C=C (OC) C (NC (/C=C/CN5CCOCC5) =O) =C4
Molecular Formula
C27H29N7O4
Molecular Weight
515.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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