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GNF-6

GNF-6 (Compound 14) is an ATP-competitive inhibitor effective against BCR-ABL and its gatekeeper T315I mutant, with IC50 values ranging from 0.09 to 0.59 μM. It stabilizes the inactive DFG-out conformation by disrupting the hydrophobic spine, making it a valuable chemical probe for studying kinase resistance mechanisms in chronic myeloid leukemia research.

Product Specifications

CAS Number

839708-29-1

Field of Research

Cardiovascular Research, Signal Transduction

Smiles

O=C1N (CC=2C (N1C) =NC (N) =NC2) C3=CC (NC (=O) C4=CC (C (F) (F) F) =CC=C4) =CC=C3C

Molecular Formula

C22H19F3N6O2

Molecular Weight

456.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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