GRL-190-21
GRL-190-21 (compound 5e) is a potent and selective SARS-CoV-2 main protease (Mpro) inhibitor, exhibiting sub-nanomolar enzyme affinity (K_i = 0.04 nM) and antiviral activity (EC_50 = 0.26 μM) in VeroE6 cells. It effectively suppresses viral replication and cytopathic effects in vitro, serving as a valuable tool compound for research into coronavirus pathogenesis and antiviral drug discovery.
Product Specifications
CAS Number
2755957-14-1
Field of Research
Infectious Disease & Virology
Smiles
C (N[C@@H] (C[C@H]1C (=O) NCCC1) C#N) (=O) [C@@H]2[C@@]3 ([C@@] (C3 (C) C) (CN2C ([C@@H] (NC (C (F) (F) F) =O) [C@@] (C) (C) C) =O) [H]) [H]
Molecular Formula
C24H34F3N5O4
Molecular Weight
513.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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