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GSK_WRN3

GSK_WRN3 is a selective, covalent inhibitor of the WRN protease (IC50 = 8.6 μM) that targets Cys727. It suppresses the growth of MSI tumor models in vitro by inducing DNA double-strand breaks and blocking proliferation, making it a valuable tool for oncology research on DNA damage response pathways.

Product Specifications

CAS Number

2923009-50-9

Field of Research

Cell Biology, Molecular Biology

Smiles

OC1=C (NC (=O) C (C (N[C@@H]2C=CS (=O) (=O) C2) =O) =C1) C3CCCCC3

Molecular Formula

C16H20N2O5S

Molecular Weight

352.40

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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