Tagtociclib (hydrate)
Product Specifications
UNSPSC Description
PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2).
Target Antigen
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-07104091-hydrate.html
Smiles
O=C(C1=CC(COC)=NN1C)NC2=NNC([C@](CC3)([H])C[C@@H]3OC(NC(C)C)=O)=C2.[H]O[H]
Molecular Weight
422.48
References & Citations
[1]Douglas Carl BEHENNA, et al. Cdk2 inhibitors. WO2020157652A2.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137894A/Tagtociclib-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137894A/Tagtociclib-hydrate-SDS-MedChemExpress.pdf
CAS Number
2733575-91-0
Available Sizes
Curated Selection
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