Tagtociclib (hydrate)
PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2) .
Product Specifications
CAS Number
[2733575-91-0]
Product Name Alternative
PF-07104091 (hydrate)
UNSPSC
12352005
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-07104091-hydrate.html
Purity
99.73
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(COC)=NN1C)NC2=NNC([C@](CC3)([H])C[C@@H]3OC(NC(C)C)=O)=C2.[H]O[H]
Molecular Formula
C19H30N6O5
Molecular Weight
422.48
References & Citations
[1]Douglas Carl BEHENNA, et al. Cdk2 inhibitors. WO2020157652A2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137894A/Tagtociclib-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137894A/Tagtociclib-hydrate-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CDK2
Available Sizes
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