ITF5924

ITF5924 is a highly selective and potent HDAC6 inhibitor (IC50 = 7.7 nM) featuring a difluoromethyl-1,3,4-oxadiazole moiety. It acts as a slow-binding substrate analog, forming a stable, long-lasting complex with the enzyme after catalytic ring opening. This inhibitor is a valuable chemical tool for probing HDAC6 function in oncology and neurology research models.