KT-333 ammonium
KT-333 ammonium is a molecular glue degrader that selectively targets STAT3 for ubiquitin-proteasome degradation by recruiting the VHL E3 ligase. It demonstrates potent antitumor activity in research models of hematologic malignancies such as T-cell lymphomas and leukemias, supporting its use in both in vitro and in vivo oncology studies.
Product Specifications
CAS Number
2839758-34-6
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
ClC (C (CCCC (N[C@@H] (C (C) (C) C) C (N1[C@@H] (C[C@H] (C1) O) C (N[C@H] (C2=CC=C (C3=C (N=CS3) C) C=C2) C) =O) =O) =O) =CC=C4) =C4OC[C@H] (CCC (N) =O) NC ([C@H]5N6[C@] (CCN (C[C@@H] (C6=O) NC (C7=CC8=CC (C (P (O) ([O-]) =O) =O) =CC=C8N7) =O) C (C) =O) ([H]) CC5) =O.[NH4+]
Molecular Formula
C60H77ClN11O14PS
Molecular Weight
1274.81
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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