Calderasib
Calderasib (MK-1084) is a potent and selective KRAS G12C inhibitor (IC50 = 1.2 nM) for research into KRAS-driven cancers. It demonstrates antitumor efficacy in both cellular and animal models and is being investigated as a single agent or combined with immune checkpoint inhibitors like pembrolizumab.
Product Specifications
CAS Number
2641216-67-1
Product Name Alternative
MK1084, MK-1084
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.69% (May vary between batches)
Solubility
DMSO:80 mg/mL (125.57 mM)
Smiles
O=C1N2C=3C (C (=N1) N4C (C) CN (C (C=C) =O) C (C) C4) =CC (Cl) =C (N3) C=5C (=C (F) C=CC5F) OCCOC=6C2=C (C (C) C) N=CC6
Molecular Formula
C32H31ClF2N6O4
Molecular Weight
637.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV726732 1.0 µg DNA
GLC3C Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
BNC472561-500 1x 500 µL
NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
CPB-869RH 100 ul
Rabbit Anti-Human SUFU Polyclonal Antibody, Phospho-Ser342
Sign In for Pricing
View Details 