Calderasib
Calderasib (MK-1084) is a potent and selective KRAS G12C inhibitor (IC50 = 1.2 nM) for research into KRAS-driven cancers. It demonstrates antitumor efficacy in both cellular and animal models and is being investigated as a single agent or combined with immune checkpoint inhibitors like pembrolizumab.
Product Specifications
CAS Number
2641216-67-1
Product Name Alternative
MK1084, MK-1084
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.69% (May vary between batches)
Solubility
DMSO:80 mg/mL (125.57 mM)
Smiles
O=C1N2C=3C (C (=N1) N4C (C) CN (C (C=C) =O) C (C) C4) =CC (Cl) =C (N3) C=5C (=C (F) C=CC5F) OCCOC=6C2=C (C (C) C) N=CC6
Molecular Formula
C32H31ClF2N6O4
Molecular Weight
637.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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