NBI 35965 hydrochloride

NBI 35965 hydrochloride is a potent, brain-penetrant, and orally active CRF1 receptor antagonist (K i = 4 nM) that selectively inhibits CRF-induced ACTH release in vivo and demonstrates anxiolytic activity. It is a valuable research tool for investigating stress-related disorders, including anxiety and depression, in both in vitro binding assays and in vivo behavioral models.