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NIC-12

NIC-12 is a selective NLRP3 inflammasome inhibitor. It effectively lowers plasma IL-1β in LPS-challenged mice and suppresses NLRP3 activation in murine macrophages, making it a valuable tool for studying inflammation in both in vivo endotoxemia models and in vitro cellular assays.

Product Specifications

CAS Number

2409826-23-7

Field of Research

Immunology & Inflammation

Smiles

C (C) (C) C=1N2C3=C (C=C2C (=O) N (CC (N[C@H]4CN (CC5CC5) CCC4) =O) N1) SC (Cl) =C3

Molecular Formula

C22H28ClN5O2S

Molecular Weight

462.01

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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