NLRP3-IN-25
NLRP3-IN-25 (compound 32) is a potent, orally bioavailable NLRP3 inhibitor with an IC50 of 21 nM for IL-1β secretion in THP-1 cells. It demonstrates anti-inflammatory efficacy in vivo by reducing renal injury in a mouse model of doxorubicin-induced glomerulonephritis, supporting research into NLRP3-driven inflammatory diseases.
Product Specifications
CAS Number
2660230-90-8
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
N (C1=CC (C (F) (F) F) =CC=C1C) C2=NC (C (NS (=O) (=O) N3CCCOCC3) =O) =CO2
Molecular Formula
C17H19F3N4O5S
Molecular Weight
448.42
Storage Conditions
-20°C
Notes
For research use only.
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