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NLRP3-IN-25

NLRP3-IN-25 (compound 32) is a potent, orally bioavailable NLRP3 inhibitor with an IC50 of 21 nM for IL-1β secretion in THP-1 cells. It demonstrates anti-inflammatory efficacy in vivo by reducing renal injury in a mouse model of doxorubicin-induced glomerulonephritis, supporting research into NLRP3-driven inflammatory diseases.

Product Specifications

CAS Number

2660230-90-8

Field of Research

Cell Biology, Immunology & Inflammation

Smiles

N (C1=CC (C (F) (F) F) =CC=C1C) C2=NC (C (NS (=O) (=O) N3CCCOCC3) =O) =CO2

Molecular Formula

C17H19F3N4O5S

Molecular Weight

448.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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