PF-477736 2HCl
PF-477736 is a potent and selective CHK1 kinase inhibitor used in research to sensitize cancer cells to DNA-damaging chemotherapies. It has demonstrated synergistic effects in preclinical in vitro and in vivo models, particularly in tumors with defective p53 pathways, supporting its investigation in oncology research.
Product Specifications
CAS Number
1247874-19-6
Smiles
O=C1C2=C3C (C=NN1) =C (C4=CN (C) N=C4) NC3=CC (NC ([C@@H] (C5CCCCC5) N) =O) =C2.Cl.Cl
Molecular Formula
C22H27Cl2N7O2
Molecular Weight
492.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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