MN-25
MN-25 (compound 4a) is an orally bioavailable indole pyridinone acting as a novel cannabinoid receptor ligand, with a binding preference for CB2 (Ki=11 nM) over CB1. It functions as a CB2 agonist, inhibiting TNF-α release in vitro (IC50=33 μM), though it showed no efficacy in a murine acute inflammation model at 50 mg/kg orally. This compound is a research tool for studying CB2 receptor pharmacology in immunomodulation and inflammation.
Product Specifications
CAS Number
501926-82-5
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C (CN1CCOCC1) N2C=3C (C (C (N[C@H]4[C@]5 (C) C[C@] (C4 (C) C) (CC5) [H]) =O) =C2) =CC=CC3OC
Molecular Formula
C26H37N3O3
Molecular Weight
439.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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