LDHA-IN-9

LDHA-IN-9 (Compound 1g) is a potent LDH-A inhibitor with an IC50 of 25 nM. It demonstrates anti-proliferative effects in DLD-1 cells (GI50 27 μM) via apoptosis induction and shows in vivo antitumor activity at 25 mg/kg in mouse models with minimal toxicity, supporting its use in cancer metabolism research.