IRF1-IN-1
IRF1-IN-1 is a small molecule inhibitor of IRF1 that blocks its recruitment to the Caspase 1 promoter, thereby suppressing the cleavage of downstream targets like GSDMD, IL-1β, and PARP1. This mechanism has shown protective effects against skin inflammation in relevant research models, making it a useful tool for studying pyroptosis and inflammatory dermatoses in vitro and in vivo.
Product Specifications
CAS Number
701225-07-2
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry
Purity
99.88% (May vary between batches)
Solubility
DMSO:80 mg/mL (181.6 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (11.35 mM)
Smiles
O=C1C=2C=CC=CC2N=CN1CCC (=O) NC3=CC=C (C=C3) S (=O) (=O) N4CCCCC4
Molecular Formula
C22H24N4O4S
Molecular Weight
440.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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