Clofarabine-5'-diphosphate
Clofarabine-5'-diphosphate (Clofarabine-DP) is the active diphosphorylated metabolite of the nucleoside analog Clofarabine, formed via phosphorylation by deoxycytidine kinase. It serves as a precursor to the triphosphate form, which inhibits DNA synthesis and repair, providing a mechanism for its cytotoxicity in cancer research models, both in vitro and in vivo.
Product Specifications
CAS Number
167620-89-5
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Smiles
F[C@@H]1[C@H] (N2C=3C (N=C2) =C (N) N=C (Cl) N3) O[C@H] (COP (OP (=O) (O) O) (=O) O) [C@H]1O
Molecular Formula
C10H13ClFN5O9P2
Molecular Weight
463.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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