LY 295427

LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor) . LY 295427 can be used for hypercholesterolemia research[1][2][3].

Product Specifications

CAS Number

[152755-31-2]

Product Name Alternative

Agisterol

UNSPSC

12352211

Target

LDLR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ly-295427.html

Purity

98.0

Solubility

Methanol : 15.91 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(CCC[C@H]([C@H]1CC[C@]2([C@@]3(CC[C@]4([C@@H]([C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)CC=C)[H])[H])[H])C)C

Molecular Formula

C30H52O

Molecular Weight

428.73

References & Citations

[1]Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37 (12) :2586-98.|[2]George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5.|[3]Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289 (1) :85-92.