UKH-1114

UKH-1114 is a potent and selective σ2 receptor/Tmem97 agonist (Ki = 46 nM) with demonstrated antinociceptive efficacy. It effectively reverses nerve injury-induced mechanical hypersensitivity in murine models without motor deficits, making it a valuable research tool for investigating neuropathic pain mechanisms in both in vitro and in vivo studies.