Isosorbide dinitrate

Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) [1].

Product Specifications

CAS Number

[87-33-2]

Product Name Alternative

ISDN

UNSPSC

12352005

Hazard Statement

H302, H312, H319

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/isosorbide-dinitrate.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H][C@]12OC[C@H](O[N+]([O-])=O)[C@]1(OC[C@H]2O[N+]([O-])=O)[H]

Molecular Formula

C6H8N2O8

Molecular Weight

236.14

Precautions

H302, H312, H319

References & Citations

[1]Wang X , et al. Intratracheal administration of isosorbide dinitrate improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction. Exp Ther Med. 2017 Aug;14 (2) :1399-1408.|[2]Zhao X, et al. Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo. Med Sci Monit. 2019 Mar 2;25:1629-1636.