PPL agonist-1
PPL agonist-1 (Compound I-3) is a selective periplakin (PPL) agonist that elevates cAMP, upregulates MITF, and modulates tryptophan metabolism to stimulate melanogenesis. It demonstrates superior efficacy to Ruxolitinib in preclinical models, showing potential for vitiligo research in both cellular and animal studies.
Product Specifications
CAS Number
3040997-52-9
Field of Research
Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction
Smiles
CC=1C=C (C2=CC=C ([C@@H] (NC=3N=C (NS (=O) (=O) C4=CC (N (=O) =O) =CC=C4) C=CN3) C) C=C2) C=CC1F
Molecular Formula
C25H22FN5O4S
Molecular Weight
507.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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