Octachlorodibenzo-p-dioxin

Octachlorodibenzo-p-dioxin (OCDD) is a persistent environmental contaminant exhibiting low acute toxicity but a long elimination half-life of 3-5 months in rats, leading to bioaccumulation in liver and adipose tissue. It induces hepatic cytochrome P-450 enzymes, specifically increasing 7-ethoxyresorufin-O-deethylase (7-EROD) activity, making it a relevant compound for studying chronic toxicity and xenobiotic metabolism in research models.