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JCS-1

JCS-1 is a potent, nanomolar DcpS PROTAC degrader (DC50 = 87 nM in MOLM-14 cells) that utilizes an RG3039-based warhead to recruit the VHL E3 ligase. This tool compound enables the study of DcpS-dependent mechanisms in acute myeloid leukemia research and related genetic disorders in cellular models.

Product Specifications

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Molecular Formula

C62H79N9O12S

Molecular Weight

1174.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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