JCS-1
JCS-1 is a potent, nanomolar DcpS PROTAC degrader (DC50 = 87 nM in MOLM-14 cells) that utilizes an RG3039-based warhead to recruit the VHL E3 ligase. This tool compound enables the study of DcpS-dependent mechanisms in acute myeloid leukemia research and related genetic disorders in cellular models.
Product Specifications
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Molecular Formula
C62H79N9O12S
Molecular Weight
1174.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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