PROTAC ERα Degrader-10
PROTAC ERα Degrader-10 (Compound 160a) is a potent, orally active small molecule that degrades ERα with low nM DC50 values in breast cancer cell lines. It has shown promising in vivo antitumor efficacy in mouse models, supporting its use in oncology research for studying ERα-driven cancers and targeted protein degradation.
Product Specifications
CAS Number
2421260-43-5
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
C (=C (/CC) \C1=CC=CC=C1) (\C2=CC=C (C=C2) N3CCC (CN4CCN (CC4) C=5C=C6C (=CC5) C (=O) N (C6) [C@@H]7C (=O) NC (=O) CC7) CC3) /C8=CC=C (O) C=C8
Molecular Formula
C45H49N5O4
Molecular Weight
723.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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