Topoisomerase I inhibitor 17
Topoisomerase I inhibitor 17 (Compound 7h) is a small molecule that induces Top1-mediated DNA damage and ROS, leading to apoptosis and G2/M arrest. It effectively inhibits colorectal cancer cell proliferation, migration, and tumor growth in PDX models, making it a valuable tool for oncology research.
Product Specifications
CAS Number
2413582-45-1
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C) C=1C=C (C2=C3C (C=4N (C3) C (=O) C5=C (C4) [C@] (CC) (O) C (=O) OC5) =NC=6C2=CC7=C (C6) OCO7) C=CC1F
Molecular Formula
C28H21FN2O7
Molecular Weight
516.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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