TOPOI/PARP-1-IN-2

TOPOI/PARP-1-IN-2 (6c) is a potent dual inhibitor of PARP-1 (IC50=32.2 nM) and topoisomerase I (IC50=46.2 nM) with selectivity over PARP-2. It induces S-phase arrest and apoptosis in cancer cell lines, making it a valuable chemical probe for studying DNA damage response and combination therapies in preclinical cancer research.