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HPK1-IN-52

HPK1-IN-52 is a potent and orally bioavailable small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of 10.4 nM. It demonstrates anti-tumor activity in research models, supporting its investigation in immuno-oncology for enhancing T cell function both in vitro and in vivo.

Product Specifications

CAS Number

2994298-66-5

Field of Research

Signal Transduction

Smiles

N (C1=C2C (=C (C=C1) C=3N4C (=NC3) C=C (F) C=C4) C=CNC2=O) C=5N=C (CN6C[C@@H] (F) CC6) C (=CC5) C7CCOCC7

Molecular Formula

C31H30F2N6O2

Molecular Weight

556.61

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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