Hypocrellin B

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].

Product Specifications

CAS Number

[123940-54-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Fungal; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/hypocrellin-b.html

Purity

99.61

Solubility

DMSO : < 1 mg/mL (ultrasonic)

Smiles

CC(C1)=C(C(C)=O)C(C2=C(C3=C(O)C=C4OC)C4=C5C(OC)=CC(O)=C6C5=C2C1=C(OC)C6=O)=C(OC)C3=O

Molecular Formula

C30H24O9

Molecular Weight

528.51

Precautions

H302, H315, H319

References & Citations

[1]Miller GG, et al. Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update. Photochem Photobiol. 1997 Apr;65 (4) :714-22.|[2]Wang X, et al. Hypocrellin B-mediated sonodynamic action induces apoptosis of hepatocellular carcinoma cells. Ultrasonics. 2012 Apr;52 (4) :543-6.|[3]Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48 (11) :4450-2.|[4]Chang JE, et al. Hypocrellin B and paclitaxel-encapsulated hyaluronic acid-ceramide nanoparticles for targeted photodynamic therapy in lung cancer. J Photochem Photobiol B. 2016 May;158:113-21.