EGFR/PI3Kα-IN-1

EGFR/PI3Kα-IN-1 (compound 30k) is a potent dual inhibitor targeting both EGFR (L858R/T790M mutant, IC50=3.6 nM) and PI3Kα (IC50=30 nM) . It demonstrates robust anti-proliferative effects in cancer cell studies and has shown significant in vivo antitumor efficacy in preclinical research models.