XD2-149
XD2-149 is a PROTAC molecule designed to degrade STAT3, utilizing Napabucasin as the warhead and a Thalidomide-based ligand for E3 ligase recruitment connected via a specified linker. This compound is a research tool for investigating STAT3-dependent pathways and has been employed in both in vitro and in vivo studies to explore targeted protein degradation as a therapeutic strategy.
Product Specifications
CAS Number
2710221-08-0
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NCCN1CCC (CC1) CCCCCNC2=CC=CC=3C (=O) N (C (=O) C23) C4C (=O) NC (=O) CC4) C=5OC=6C (=O) C=7C=CC=CC7C (=O) C6C5
Molecular Formula
C38H39N5O8
Molecular Weight
693.75
Storage Conditions
-20°C
Notes
For research use only.
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