Skp2 inhibitor 3

Skp2 inhibitor 3 (E35) is a potent small molecule that disrupts the Skp2-Cks1 interaction (IC50 = 4.86 μM) . It demonstrates robust antitumor activity in vitro by inhibiting cancer cell colony formation and migration, while inducing S-phase cell cycle arrest. This makes it a valuable research tool for studying Skp2-dependent oncogenesis and cell cycle regulation.