SMARCA2-IN-8

SMARCA2-IN-8 (Compound 13) is a potent, orally bioavailable dual inhibitor of SMARCA2/BRM and SMARCA4/BRG1 with low nM IC50 values. It suppresses proliferation and target gene expression in SMARCA2-mutant cancer cells in vitro and demonstrates in vivo antitumor efficacy in mouse models, supporting its use in oncology research targeting SWI/SNF chromatin remodelers.